聚偏氟乙烯膜表面功能基团比例及亲疏水平衡对其血液相容性的影响

The technology of this project is based on controlling functional group ratios and hydrophilic-hydrophobic balance on polyvinylidene fluoride (PVDF) membrane surface to improve the blood compatibility of PVDF membrane. Firstly, in situ crosslinked polymerization/copolymerization is carried out to prepare PVDF membrane-forming solution, which contains carboxyl, hydroxyl and sulfonic group. Then, modified PVDF membrane is prepared by phase inversion technology. The carboxyl, hydroxyl and sulfonic group can enrich on the surface of the modified PVDF membrane, resulting in the improvement of hydrophilicity of the modified PVDF membrane. The key event of this project is to study the relationship between the surface functional group ratios, hydrophilic-hydrophobic balance and blood compatibility of modified PVDF membrane surface, which can lay the foundation for preparing the blood compatible PVDF membrane. Meanwhile, this project will provide theoretical basis for the researches of implantable artificial organs and small-diameter vascular grafts.

本项目利用羧基、磺酸基、羟基等亲水性功能基团调控聚偏氟乙烯（PVDF）膜表面功能基团比例及亲疏水平衡，制备具有良好血液相容性的改性PVDF膜。首先通过原位交联聚合/共聚合的方法合成制备带有羧基、磺酸基、羟基等亲水基团的功能性PVDF成膜液。将带有这些亲水性功能基团的PVDF成膜液直接相转化成膜，制备表面带有羧基、磺酸基、羟基等亲水性功能基团的功能型PVDF膜。研究不同含量的羧基、磺酸基、羟基等亲水性功能基团对PVDF膜表面亲疏水性以及血液相容性的影响；研究改性PVDF膜表面亲水性功能基团种类及比例与凝血系统的相互作用。为制备优异血液相容性的PVDF膜奠定基础，同时为研究植入型人工器官和小口径人工血管提供理论基础。

本项目利用羧基、羟基等亲水性功能基团调控聚偏氟乙烯（PVDF）膜表面功能基团比例及亲疏水平衡，制备具有良好血液相容性的改性PVDF膜。首先通过原位交联聚合/共聚合的方法合成制备带有羧基、羟基等亲水基团的功能性PVDF成膜液。将带有这些亲水性功能基团的PVDF成膜液直接相转化成膜，制备表面带有羧基、羟基等亲水性功能基团的功能型PVDF膜。研究不同含量的羧基、羟基等亲水性功能基团对PVDF膜表面亲疏水性以及血液相容性的影响。结果证明，通过亲水性功能基团与氟化表面的结合可以有效地在提高PVDF抗凝性的基础上抑制其与血液接触带来的血液系统的接触激活。此结论为制备优异血液相容性的PVDF膜奠定基础，同时为研究植入型人工器官和小口径人工血管提供理论基础。