钐-153烷基膦酸类配合物构效关系研究

Seven phosphonate ligands were synthesized according to Mannich Reaction Principle. Then the complexing conditions of the ligands with 153Sm3+ together with the biochemical properties of these complexes were investigated.In the preparation of these 153Sm-complexes, it is found that structure parameters of the ligand molecule such as the number of -PO3H2, the stereoscopic distance between them and so on affected the preparation of 153Sm-complexes. In the investigation of the biochemical properties, it is found that there was a discrepancy between bone uptake in mice and adsorption on bone model material, and this discrepancy could be explained when some biochemical parameters were considered. The molecular modeling software Material Studio 2.0 was employed to build the molecular models for these 153Sm-complexes and a satisfactory QSAR equation was deduced by using QSAR analysis software TsarTM3.3 for bone uptake (BU, unit:ID%/g ) 2 hours post injection. These research results are very useful for designation of better pharmaceuticals aimed at bone tumour, and several new promising ligands of our own right have come into being through this research.

本项目选择多种膦酸配体，研究与钐形成配合物的化学、生化、生物学性质，揭痉派湫灶天⑺崤浜衔镒魑侵琢鲋瘟埔┪锏墓巧闳。９怯氩”涔侵闳”群脱宄炔问肱浜衔锏幕А⑸灾实墓叵狄约芭浜衔锏墓巧慊怼＝㈩蹋?53的骨肿瘤治疗药物的构效关系，为设计合成新型骨肿瘤治疗药物提供理论依据。