基于石墨烯折射率传感的光声显微成像技术与应用研究

According to the current detection of photoacoustic imaging with narrow bandwidth, low sensitivity, poor resolution and other key issues for the team on the basis of previous study of this project, to be nearly a few years of vigorous development of new optical surface wave sensor detection technology into the field of photoacoustic imaging, a novel optical wave ultra high sensitivity, large bandwidth light based on acoustic imaging. The research contents include: constructing the theoretical model of surface wave propagation and coupling of light waves, light intensity, clear mechanism of acoustic frequency on solution refractive index and surface wave intensity, phase change; development of SPR/ graphene surface wave differential model of photoacoustic signal detection technology based on interferometric sensing, and the development of new photoacoustic imaging system based on the optical surface, with ultra high sensitivity (~10Pa) and large bandwidth (0~500MHz bandwidth) and high spatial resolution (level <500nm, longitudinal <10 u m) and other advantages; on the basis of study on neovascularization of photoacoustic imaging application development in tumor tissue, study the anticancer drugs to the tumor occurrence and metastasis the inhibitory effect, provide the basis for the clinical application of anti tumor drugs.

针对当前光声成像技术面临的探测带宽窄、灵敏度低、成像分辨率差等关键问题，本项目申请团队在前期研究基础上，拟将近几年蓬勃发展的新型光学表面波传感探测技术引入光声成像领域，开展基于光学表面波的新型超高灵敏、超大带宽光声显微成像研究。研究内容包括：构建光声波对表面波传播与耦合影响的理论模型，明确光声波强度、频率对溶液折射率变化和表面波强度、位相变化的作用机理；发展基于SPR/石墨烯表面波差分干涉传感的新型光声信号探测技术，并研发基于光学表面波的新型光声显微成像系统，具备超高灵敏度（~10Pa 水平）、超大带宽（0~500MHz 带宽）、高空间分辨率（水平<500nm，纵向<10μm）等优势；在此基础上，开展肿瘤组织中的新生血管等光声成像应用研究，研究抗癌药物对肿瘤发生和转移的抑制效用，为抗肿瘤药物的临床应用提供依据。

本项目针对当前光声成像技术面临的探测带宽窄、灵敏度低、成像分辨率差等关键问题，本项目申请团队在前期研究基础上，将近几年蓬勃发展的新型光学表面波传感探测技术引入光声成像领域，开展基于光学表面波的新型超高灵敏、超大带宽光声显微成像研究。研究成果包括：构建光声波对表面波传播与耦合影响的理论模型，明确光声波强度、频率对溶液折射率变化和表面波强度、位相变化的作用机理；发展基于SPR/石墨烯表面波差分干涉传感的新型光声信号探测技术，并研发基于光学表面波的新型光声显微成像系统，具备超高灵敏度（~100Pa 水平）、超大带宽（0~225MHz 带宽）、高空间分辨率（水平约0.6um，纵向约7.6μm）等优势；在此基础上，开展肿瘤组织中的新生血管等光声成像应用研究，研究抗癌药物对肿瘤发生和转移的抑制效用，为抗肿瘤药物的临床应用提供依据。共发表论文8篇，申请并获得授权专利4项，培养学生7名，顺利完成项目。